Sasa borealis Ethanol Extract Protects PC12 Neuronal Cells against Oxidative Stress

The overproduction of reactive oxygen species (ROS) can cause oxidative stress to biomolecules such as nucleic acids, proteins, and lipids, leading neurodegenerative disorders. Sasa borealis (SB) has antioxidant, anti-inflammatory, antidiabetic, anti-obesity effects. We evaluated the neuroprotective activity SB on hydrogen peroxide (H2O2)-induced stress. investigated antioxidant effects water extract (SBW) ethanol (SBE) by measuring radical scavenging activities intracellular ROS production. SBE, which had a high level isoorientin, higher antioxidative than SBW in 2,2?-azino-bis-(3-ethylbenzothiazolin-6-sulfonic acid) diammonium salt (ABTS+) 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays. It also reduced generation pheochromocytoma 12 (PC12) cells more significantly SBW. increased translation heme oxygenase-1 (HO-1), superoxide dismutase 2 (SOD2), catalase (CAT), glutathione peroxidase (GPx) with corresponding increase NF-E2-related factor-2 (Nrf-2). In conclusion, SBE levels phenolic compounds isoorientin shows promise for preventing diseases.